Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC7298616 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Guo Jingtao J Nie Xichen X Giebler Maria M Mlcochova Hana H Wang Yueqi Y Grow Edward J EJ Kim Robin R Tharmalingam Melissa M Matilionyte Gabriele G Lindskog Cecilia C Carrell Douglas T DT Mitchell Rod T RT Goriely Anne A Hotaling James M JM Cairns Bradley R BR
Cell stem cell 20200109 2
The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the onset of spermatogenesis. To characterize this understudied process, we profiled and analyzed single-cell transcriptomes of ∼10,000 testicular cells from four boys spanning puberty and compared them to those of infants and adults. During puberty, undifferentiated spermatogonia sequentially expand and differentiate prior to the initiation ...[more]