Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC7298650 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
iScience 20200523 6
Although insulin is a life-saving medicine, administration by daily injection remains problematic. Our goal was to exploit the power of DNA-encoded libraries to identify molecules with insulin-like activity but with the potential to be developed as oral drugs. Our strategy involved using a 10<sup>4</sup>-member DNA-encoded library containing 160 Traditional Chinese Medicines (nDEL) to identify molecules that bind to and activate the insulin receptor. Importantly, we used the natural ligand, insu ...[more]