Cerebral organoids transplantation improves neurological motor function in rat brain injury.

ABSTRACT:

Background and purpose

Cerebral organoids (COs) have been used for studying brain development, neural disorders, and species-specific drug pharmacology and toxicology, but the potential of COs transplantation therapy for brain injury remains to be answered.

Methods

With preparation of traumatic brain injury (TBI) model of motor dysfunction, COs at 55 and 85 days (55 and 85 d-CO) were transplanted into damaged motor cortex separately to identify better transplantation donor for brain injury. Further, the feasibility, effectiveness, and underlying mechanism of COs transplantation therapy for brain injury were explored.

Results

55 d-CO was demonstrated as better transplantation donor than 85 d-CO, evidenced by more neurogenesis and higher cell survival rate without aggra

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7298981 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature