Ontology highlight
ABSTRACT:
SUBMITTER: Lee TW
PROVIDER: S-EPMC7299346 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lee Teresa Wei-Sy TW David Heidi Shira HS Engstrom Amanda Kathryn AK Carpenter Brandon Scott BS Katz David John DJ
eLife 20191209
In <i>Caenorhabditis elegans</i>, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that <i>wdr-5</i> mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin factor H3K9me2 over twenty generations. In addition, we find that the transgenerational aspects of <i>wdr-5</i> mutant longevity require the H3K9me2 methyltransferase MET-2, and can be r ...[more]