Elevated galectin-3 in women with gestational diabetes mellitus, a new surrogate for cardiovascular disease in women.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is associated with future cardiovascular morbidity and recognized as a women-specific risk factor for cardiovascular disease. The mechanisms for this association are not well established. Therefore, we aimed to evaluate the cardiovascular-related biomarkers, galectin-3 (Gal-3) and protein convertase subtilisin/kexin (PCSK) type 9, in women with GDM.

Methods

Blood samples were drawn in the third trimester from 31 women diagnosed with GDM and from 35 women with normal pregnancies. Blood levels of Gal-3 and PCSK-9 were measured using a quantitative sandwich enzyme immunoassay. In addition, we measured Gal-3 levels in 24 pregnant women in the first trimester who later developed GDM and in 36 healthy controls. Continuous variables we

SUBMITTER: Talmor-Barkan Y 

PROVIDER: S-EPMC7299386 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature