Ontology highlight
ABSTRACT:
SUBMITTER: Rosikiewicz W
PROVIDER: S-EPMC7299612 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science advances 20200617 25
The TET2 DNA hydroxymethyltransferase is frequently disrupted by somatic mutations in diffuse large B cell lymphomas (DLBCLs), a tumor that originates from germinal center (GC) B cells. Here, we show that TET2 deficiency leads to DNA hypermethylation of regulatory elements in GC B cells, associated with silencing of the respective genes. This hypermethylation affects the binding of transcription factors including those involved in exit from the GC reaction and involves pathways such as B cell re ...[more]