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Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope.

ABSTRACT: Developmental shifts in stage-specific gene expression can provide a ready mechanism of phenotypic change by altering the rate or timing of ontogenetic events. We found that the high-altitude Tibetan antelope (Panthelops hodgsonii) has evolved an adaptive increase in blood-O₂ affinity by truncating the ancestral ontogeny of globin gene expression such that a high-affinity juvenile hemoglobin isoform (isoHb) completely supplants the lower-affinity isoHb that is expressed in the adult red blood cells of other bovids. This juvenilization of blood properties represents a canalization of an acclimatization response to hypoxia that has been well documented in adult goats and sheep. We also found the genomic mechanism underlying this regulatory isoHb switch, revealing how a reversible acclimatization response became genetically assimilated as an irreversible adaptation to chronic hypoxia.

SUBMITTER: Signore AV

PROVIDER: S-EPMC7299627 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope.

Signore Anthony V AV Storz Jay F JF

Science advances 20200617 25

Developmental shifts in stage-specific gene expression can provide a ready mechanism of phenotypic change by altering the rate or timing of ontogenetic events. We found that the high-altitude Tibetan antelope (<i>Panthelops hodgsonii</i>) has evolved an adaptive increase in blood-O<sub>2</sub> affinity by truncating the ancestral ontogeny of globin gene expression such that a high-affinity juvenile hemoglobin isoform (isoHb) completely supplants the lower-affinity isoHb that is expressed in the ...[more]

PMID: 32596473

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