Ontology highlight
ABSTRACT:
SUBMITTER: Mittal K
PROVIDER: S-EPMC7299818 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Mittal Karuna K Toss Michael S MS Wei Guanhao G Kaur Jaspreet J Choi Da Hoon DH Melton Brian D BD Osan Remus M RM Miligy Islam M IM Green Andrew R AR Janssen Emiel A M EAM Søiland Håvard H Gogineni Keerthi K Manne Upender U Rida Padmashree P Rakha Emad A EA Aneja Ritu R
Clinical cancer research : an official journal of the American Association for Cancer Research 20200114 12
<h4>Purpose</h4>The purpose of this study is to predict risk of local recurrence (LR) in ductal carcinoma <i>in situ</i> (DCIS) with a new visualization and quantification approach using centrosome amplification (CA), a cancer cell-specific trait widely associated with aggressiveness.<h4>Experimental design</h4>This first-of-its-kind methodology evaluates the severity and frequency of numerical and structural CA present within DCIS and assigns a quantitative centrosomal amplification score (CAS) ...[more]