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Usefulness of ambulatory blood pressure measurement for hypertension management in India: the India ABPM study.

ABSTRACT: The present paper reports differences between office blood pressure (BP) measurement (OBPM) and ambulatory blood pressure measurement (ABPM) in a large multi-centre Indian all comers' population visiting primary care physicians. ABPM and OBPM data from 27,472 subjects (aged 51?±?14 years, males 68.2%, treated 45.5%) were analysed and compared. Patients were classified based on the following hypertension thresholds: systolic BP (SBP)???140 and/or diastolic BP?(DBP)??90?mmHg for OBPM, and SBP???130 and/or DBP???80?mmHg for 24-h ABPM, and SBP???120 and/or DBP???70?mmHg for night-time ABPM and SBP???135 and/or DBP???85?mmHg for daytime ABPM, all together. White coat hypertension (WCH) was seen in 12.0% (n?=?3304), masked hypertension (MH) in 19.3% (n?=?5293) and 55.5% (n?=?15,246) had sustained hypertension. Isolated night-time hypertension (INH) was diagnosed in 11.9% (n?=?3256). Untreated subjects had MH relatively more often than treated subjects (23.0% vs. 14.8%, p?

SUBMITTER: Kaul U

PROVIDER: S-EPMC7299842 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Usefulness of ambulatory blood pressure measurement for hypertension management in India: the India ABPM study.

Kaul Upendra U Arambam Priyadarshini P Rao Srinivas S Kapoor Sunil S Swahney J P S JPS Sharma Kamal K Nair Tiny T Chopda Manoj M Hiremath Jagdish J Ponde C K CK Oomman Abraham A Srinivas B C BC Suvarna Viraj V Jasuja Sanjiv S Borges Eric E Verberk Willem J WJ

Journal of human hypertension 20190904 6

The present paper reports differences between office blood pressure (BP) measurement (OBPM) and ambulatory blood pressure measurement (ABPM) in a large multi-centre Indian all comers' population visiting primary care physicians. ABPM and OBPM data from 27,472 subjects (aged 51 ± 14 years, males 68.2%, treated 45.5%) were analysed and compared. Patients were classified based on the following hypertension thresholds: systolic BP (SBP) ≥ 140 and/or diastolic BP (DBP) ≥90 mmHg for OBPM, and SBP ≥ 13 ...[more]

PMID: 31484988

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Project description:IntroductionMasked uncontrolled hypertension (MUCH) carries an increased risk of cardiovascular (CV) complications and can be identified through combined use of office (O) and ambulatory (A) blood pressure (BP) monitoring (M) in treated patients. However, it is still debated whether the information carried by ABPM should be considered for MUCH management. Aim of the MASked-unconTrolled hypERtension management based on OBP or on ambulatory blood pressure measurement (MASTER) Study is to assess the impact on outcome of MUCH management based on OBPM or ABPM.Methods and analysisMASTER is a 4-year prospective, randomised, open-label, blinded-endpoint investigation. A total of 1240 treated hypertensive patients from about 40 secondary care clinical centres worldwide will be included -upon confirming presence of MUCH (repeated on treatment OBP <140/90 mm Hg, and at least one of the following: daytime ABP ≥135/85 mm Hg; night-time ABP ≥120/70 mm Hg; 24 hour ABP ≥130/80 mm Hg), and will be randomised to a management strategy based on OBPM (group 1) or on ABPM (group 2). Patients in group 1 will have OBP measured at 0, 3, 6, 12, 18, 24, 30, 36, 42 and 48 months and taken as a guide for treatment; ABPM will be performed at randomisation and at 12, 24, 36 and 48 months but will not be used to take treatment decisions. Patients randomised to group 2 will have ABPM performed at randomisation and all scheduled visits as a guide to antihypertensive treatment. The effects of MUCH management strategy based on ABPM or on OBPM on CV and renal intermediate outcomes (changing left ventricular mass and microalbuminuria, coprimary outcomes) at 1 year and on CV events at 4 years and on changes in BP-related variables will be assessed.Ethics and disseminationMASTER study protocol has received approval by the ethical review board of Istituto Auxologico Italiano. The procedures set out in this protocol are in accordance with principles of Declaration of Helsinki and Good Clinical Practice guidelines. Results will be published in accordance with the CONSORT statement in a peer-reviewed scientific journal.Trial registration numberNCT02804074; Pre-results.

Dataset Information

Usefulness of ambulatory blood pressure measurement for hypertension management in India: the India ABPM study.

Publications

Usefulness of ambulatory blood pressure measurement for hypertension management in India: the India ABPM study.

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