Weights for ordinal analyses of the modified Rankin Scale in stroke trials: A population-based cohort study.

ABSTRACT:

Background

Ordinal/shift analyses of ordered measures like the modified Rankin Scale(mRS) are underused as primary trial outcomes for neurological disorders - despite statistical advantages - potentially hindered by poor clinical interpretability versus dichotomies, and by valuing state-transitions equally (linear scale). Weighted ordinal analyses incorporating step-changes at key transitions might have greater statistical validity and clinical applicability.

Methods

In a prospective population-based cohort of ischaemic stroke (Oxford Vascular Study, recruited 2002-2014), we stratified 5-year outcomes of death, dementia, and/or institutionalization, health/social-care costs, and EuroQol-derived quality-adjusted life-expectancy(QALE) by 3-month mRS. We compared root-mean-squa

SUBMITTER: Ganesh A 

PROVIDER: S-EPMC7300241 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature