Protein-Folding Analysis Using Features Obtained by Persistent Homology.
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ABSTRACT:
SUBMITTER: Ichinomiya T
PROVIDER: S-EPMC7300307 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Protein-Folding Analysis Using Features Obtained by Persistent Homology.
Ichinomiya Takashi T Obayashi Ippei I Hiraoka Yasuaki Y
Biophysical journal 20200505 12
Understanding the protein-folding process is an outstanding issue in biophysics; recent developments in molecular dynamics simulation have provided insights into this phenomenon. However, the large freedom of atomic motion hinders the understanding of this process. In this study, we applied persistent homology, an emerging method to analyze topological features in a data set, to reveal protein-folding dynamics. We developed a new, to our knowledge, method to characterize the protein structure ba ...[more]
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