Ontology highlight
ABSTRACT:
SUBMITTER: Avalle L
PROVIDER: S-EPMC7301178 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Avalle Lidia L Marino Francesca F Camporeale Annalisa A Guglielmi Chiara C Viavattene Daniele D Bandini Silvio S Conti Laura L Cimino James J Forni Marco M Zanini Cristina C Ghigo Alessandra A Bogorad Roman L RL Cavallo Federica F Provero Paolo P Koteliansky Victor V Poli Valeria V
Molecular therapy. Methods & clinical development 20200522
Myocarditis can lead to autoimmune disease, dilated cardiomyopathy, and heart failure, which is modeled in the mouse by cardiac myosin immunization (experimental autoimmune myocarditis [EAM]). Signal transducer and activator of transcription 3 (STAT3) systemic inhibition exerts both preventive and therapeutic effects in EAM, and STAT3 constitutive activation elicits immune-mediated myocarditis dependent on complement C3 and correlating with activation of the STAT3-interleukin 6 (IL-6) axis in th ...[more]