Cellular Adhesion Molecules in Young Adulthood and Cardiac Function in Later Life.

ABSTRACT:

Background

E-selectin and intercellular adhesion molecule (ICAM)-1 are biomarkers of endothelial activation, which has been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFpEF). However, the temporal associations between E-selectin and ICAM-1 with subclinical cardiac dysfunction are unclear.

Objectives

This study sought to assess the longitudinal associations of E-selectin and ICAM-1 with subclinical alterations in cardiac function.

Methods

In the Coronary Artery Disease Risk Development in Young Adults study, a cohort of black and white young adults, we evaluated the associations of E-selectin and ICAM-1, obtained at year (Y) 7 (Y7) and Y15 examinations, with cardiac function assessed at Y30 after adjustment for key covariates

SUBMITTER: Patel RB 

PROVIDER: S-EPMC7301611 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature