Ontology highlight
ABSTRACT:
SUBMITTER: Wong MY
PROVIDER: S-EPMC7302447 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wong May Yw MY Saad Sonia S Wong Muh Geot MG Stangenberg Stefanie S Jarolimek Wolfgang W Schilter Heidi H Zaky Amgad A Gill Anthony A Pollock Carol C
PloS one 20200618 6
Semicarbazide-sensitive amine oxidase (SSAO) is an enzyme with a unique dual function in controlling inflammation as well as reactive oxygen species (ROS) generation. We have demonstrated benefit of SSAO inhibition in acute kidney fibrosis. However the function of SSAO in chronic kidney disease (CKD) and diabetic kidney disease (DKD) is yet to be determined. We aimed to assess the effectiveness of a SSAO inhibitor (SSAOi; PXS-4728A) as an antifibrotic agent using a diabetic model of CKD. Diabeti ...[more]