Genetic variants associated with alcohol dependence co-ordinate regulation of ADH genes in gastrointestinal and adipose tissues.
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ABSTRACT:
SUBMITTER: Hibberd R
PROVIDER: S-EPMC7303195 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Genetic variants associated with alcohol dependence co-ordinate regulation of ADH genes in gastrointestinal and adipose tissues.
Hibberd Rebecca R Golovina Evgeniia E Farrow Sophie S O'Sullivan Justin M JM
Scientific reports 20200618 1
GWAS studies have identified genetic variants associated with Alcohol Dependence (AD), but how they link to genes, their regulation and disease traits, remains largely unexplored. Here we integrated information on the 3D genome organization with expression quantitative loci (eQTLs) analysis, using CoDeS3D, to identify the functional impacts of single nucleotide polymorphisms associated with AD (p < 1 × 10<sup>-6</sup>). We report that 42% of the 285 significant tissue-specific regulatory interac ...[more]
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