Dataset Information

Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.

ABSTRACT:

Objective

The ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase-amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high-frequency amplitude by low-frequency phase, is associated with audiovisual integration in adults. Thus, we investigated how PAC develops in adolescents and whether it is related to the functional maturation of audiovisual integration. In particular, we focused on the timing of PAC (or the coupling phase), which is defined as the low-frequency phase with maximum high-frequency amplitude.

Methods

Using magnetoencephalography (MEG) on 15 adults and 14 adolescents while they performed an audiovisual speech integration task, we examined PAC in association cortexes with a trial-by-trial analysis.

Results

Whereas delta-beta coupling was consistently observed in both adults and adolescents, we found that the timing of delta-beta PAC was delayed by 20-40 milliseconds in adolescents compared with adults. In addition, a logistic regression analysis revealed that the task performance improves as the timing of delta-beta PAC in the right temporal pole (TP) got closer to the trough position (180 degrees).

Conclusion

These results suggest that the timing of PAC is essential for binding audiovisual information and underlies the developmental process in adolescents.

SUBMITTER: Ohki T

PROVIDER: S-EPMC7303405 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.

Ohki Takefumi T Matsuda Takeru T Gunji Atsuko A Takei Yuichi Y Sakuma Ryusuke R Kaneko Yuu Y Inagaki Masumi M Hanakawa Takashi T Ueda Kazuhiro K Fukuda Masato M Hiraki Kazuo K

Brain and behavior 20200427 6

<h4>Objective</h4>The ability to integrate audiovisual information matures late in adolescents, but its neuronal mechanism is still unknown. Recent studies showed that phase-amplitude coupling (PAC) of neuronal oscillations, which is defined as the modulation of high-frequency amplitude by low-frequency phase, is associated with audiovisual integration in adults. Thus, we investigated how PAC develops in adolescents and whether it is related to the functional maturation of audiovisual integratio ...[more]

PMID: 32342667

Similar Datasets

Project description:Neuronal oscillations support cognitive processing. Modern views suggest that neuronal oscillations do not only reflect coordinated activity in spatially distributed networks, but also that there is interaction between the oscillations at different frequencies. For example, invasive recordings in animals and humans have found that the amplitude of fast oscillations (>40 Hz) occur non-uniformly within the phase of slower oscillations, forming the so-called cross-frequency coupling (CFC). However, the CFC patterns might be influenced by features in the signal that do not relate to underlying physiological interactions. For example, CFC estimates may be sensitive to spectral correlations due to non-sinusoidal properties of the alpha band wave morphology. To investigate this issue, we performed CFC analysis using experimental and synthetic data. The former consisted in a double-blind magnetoencephalography pharmacological study in which participants received either placebo, 0.5 or 1.5 mg of lorazepam (LZP; GABAergic enhancer) in different experimental sessions. By recording oscillatory brain activity with during rest and working memory (WM), we were able to demonstrate that posterior alpha (8-12 Hz) phase was coupled to beta-low gamma band (20-45 Hz) amplitude envelope during all sessions. Importantly, bicoherence values around the harmonics of the alpha frequency were similar both in magnitude and topographic distribution to the cross-frequency coherence (CFCoh) values observed in the alpha-phase to beta-low gamma coupling. In addition, despite the large CFCoh we found no significant cross-frequency directionality (CFD). Critically, simulations demonstrated that a sizable part of our empirical CFCoh between alpha and beta-low gamma coupling and the lack of CFD could be explained by two-three harmonics aligned in zero phase-lag produced by the physiologically characteristic alpha asymmetry in the amplitude of the peaks relative to the troughs. Furthermore, we showed that periodic signals whose waveform deviate from pure sine waves produce non-zero CFCoh with predictable CFD. Our results reveal the important role of the non-sinusoidal wave morphology on state of the art CFC metrics and we recommend caution with strong physiological interpretations of CFC and suggest basic data quality checks to enhance the mechanistic understanding of CFC.

Dataset Information

Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.

Objective

Methods

Results

Conclusion

Publications

Timing of phase-amplitude coupling is essential for neuronal and functional maturation of audiovisual integration in adolescents.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets