Ontology highlight
ABSTRACT:
SUBMITTER: Ilyas I
PROVIDER: S-EPMC7303484 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Arthroplasty today 20200226 2
Alkaptonuria is a rare metabolic disorder caused by the deficiency of homogentisic acid oxidase enzyme, which is responsible for eliminating homogentisic acid from the body through the renal system. Excessive accumulation of homogentisic acid leads to ochronosis and ochronotic arthritis. Owing to the rarity of the disease, long-term functional outcomes of joint replacements of the hips and knees in ochronosis arthropathy are unconfirmed, and only a limited number of case reports are available on ...[more]