Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis.

ABSTRACT:

Background

Ceftriaxone is the only consistently active antimicrobial agent recommended for the treatment of Neisseria gonorrhoeae. Although some new antimicrobials are in development, the necessity to expand treatment options in the near term may require using older drugs that have not been widely used to treat gonorrhoea.

Methods

We conducted a literature review of clinical trials and case series, published from 1983 to 2017, reporting treatment efficacy results following administration of 1 g aztreonam intramuscularly or IV for uncomplicated gonococcal infections. We summed trial data, stratified by anatomical site of infection, and calculated summary efficacy estimates and 95% CI for each site of infection.

Results

The 10 identified clinical trials enrolled 678, 38

SUBMITTER: Barbee LA 

PROVIDER: S-EPMC7303817 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature