Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez MC
PROVIDER: S-EPMC7303953 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Rodríguez Milagros Collados MC Dybas Joseph M JM Hughes Joseph J Weitzman Matthew D MD Boutell Chris C
Virus research 20200513
Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the cellular proteome to create an environment permissive for virus replication. HSV-1 encodes its own RING-finger E3 ubiquitin (Ub) ligase, Infected Cell Protein 0 (ICP0), that directly interfaces with component proteins of the Ub pathway to inactivate host immune defences and cellular processes that restrict the progression of HSV-1 infection. Consequently, ICP0 plays a critical role in the infectious cycle of HSV-1 that ...[more]