Dataset Information

Lipidome analysis of milk composition in humans, monkeys, bovids, and pigs.

ABSTRACT: BACKGROUND:Lipids contained in milk are an essential source of energy and structural materials for a growing neonate. Furthermore, lipids' long-chain unsaturated fatty acid residues can directly participate in neonatal tissue formation. Here, we used untargeted mass spectrometric measurements to assess milk lipid composition in seven mammalian species: humans, two macaque species, cows, goats, yaks, and pigs. RESULTS:Analysis of the main milk lipid class, triacylglycerides (TAGs), revealed species-specific quantitative differences in the composition of fatty acid residues for each of seven species. Overall, differences in milk lipid composition reflect evolutionary distances among species, with each species group demonstrating specific lipidome features. Among them, human milk contained more medium and long-chain unsaturated fatty acids compared to other species, while pig milk was the most distinct, featuring the highest proportion of long-chain polyunsaturated fatty acids. CONCLUSIONS:We show that milk lipidome composition is dynamic across mammalian species, changed extensively in pigs, and contains features particular to humans.

SUBMITTER: Mitina A

PROVIDER: S-EPMC7304121 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lipidome analysis of milk composition in humans, monkeys, bovids, and pigs.

Mitina Aleksandra A Mazin Pavel P Vanyushkina Anna A Anikanov Nikolay N Mair Waltraud W Guo Song S Khaitovich Philipp P

BMC evolutionary biology 20200619 1

<h4>Background</h4>Lipids contained in milk are an essential source of energy and structural materials for a growing neonate. Furthermore, lipids' long-chain unsaturated fatty acid residues can directly participate in neonatal tissue formation. Here, we used untargeted mass spectrometric measurements to assess milk lipid composition in seven mammalian species: humans, two macaque species, cows, goats, yaks, and pigs.<h4>Results</h4>Analysis of the main milk lipid class, triacylglycerides (TAGs), ...[more]

PMID: 32560628

Similar Datasets

Project description:ObjectivesThe fatty acid (FA) composition of breast milk is a relevant aspect related to the development of the lactating infant. The present study aimed at exploring correlations between dietary intake of macro- and micronutrients with the FA profile in breast milk, and the possible implication for infants' growth.Study designBreast milk samples from a cohort of lactating women were collected 7-15 days postpartum. The FA profiles in triacylglycerol (TAG) and phospholipid (PL)-rich fractions were analyzed by gas chromatography. Diet was registered during the third trimester of pregnancy by means of a food frequency questionnaire (FFQ). In addition, anthropometric measurements of infants were collected from gestation and up to 12 months postpartum.ResultsThe FA profile in breast milk was characterized by a median of 37.4, 41.3 and 16.8% of saturated, monounsaturated, and polyunsaturated FAs, respectively. From the dietary components, zinc, iron, and B group vitamins were correlated positively with the proportion of total n-3 FAs in TAG and C20:5 n-3 in PL. Lycopene, vitamin E, zinc, and vitamin B2 showed a similar correlation with total polyunsaturated fatty acid (PUFA), total n-6 FAs, C20:4 n-6, and C18:2 n-6 in TAG. Regarding food groups, nuts showed the strongest association with several PUFA both in TAG and PL, while the vegetable group was also positively associated with C18:3 n-3. Furthermore, the concentration of linolenic acid (C18:3 n-3) and palmitic acid (C16:0) were positively associated with increased length for age (LFA) and weight for age (WFA) at 12 months compared with birth [ΔLFA -0.16 (-0.85, 0.37); ΔWFA -0.26 (-0.77, 0.21)].ConclusionsMothers' intake of nuts, dietary sources of zinc, iron, and B group vitamins were identified as potential predictors of a high-unsaturated FA profile in breast milk. In addition, linolenic and palmitic acids in breast milk were positively associated with infants' growth in the first year of life.

Dataset Information

Lipidome analysis of milk composition in humans, monkeys, bovids, and pigs.

Publications

Lipidome analysis of milk composition in humans, monkeys, bovids, and pigs.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets