Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC7304445 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Wensheng W Chen Zhipeng Z Zhang Miaomiao M Tian Yahui Y Liu Lu L Lan Ruirui R Zeng Guandi G Fu Xiaolong X Ru Guoqing G Liu Wanting W Chen Liang L Fan Zhenzhen Z
Frontiers in oncology 20200612
Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes (TSGs) play a critical role in restricting tumorigenesis and impact the therapeutic effect of various treatments. However, TSGs remain to be systemically determined in lung cancer. Here, we identified GATA6 as a potent lung cancer TSG. GATA6 inhibited lung cancer cell growth <i>in vitro</i> and tumorigenesis <i>in vivo</i>. Mechanistically, GATA6 upregulated p53 and p21 mRNA while it inhibited AKT activat ...[more]