Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
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ABSTRACT:
SUBMITTER: Harrison OJ
PROVIDER: S-EPMC7304459 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
Harrison Oliver J OJ Linehan Jonathan L JL Shih Han-Yu HY Bouladoux Nicolas N Han Seong-Ji SJ Smelkinson Margery M Sen Shurjo K SK Byrd Allyson L AL Enamorado Michel M Yao Chen C Tamoutounour Samira S Van Laethem Francois F Hurabielle Charlotte C Collins Nicholas N Paun Andrea A Salcedo Rosalba R O'Shea John J JJ Belkaid Yasmine Y
Science (New York, N.Y.) 20181206 6422
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type 17 program associated with a poised type 2 state. Thus, in the context of injury and exposure to inflammatory mediators such as interleukin-18, these cells rapidly release type 2 cytokines, thereby acquiring ...[more]
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