Using narratives in differential diagnosis of neurodegenerative syndromes.

ABSTRACT:

Purpose

Language decline has been associated with healthy aging and with various neurodegenerative conditions, making it challenging to differentiate among these conditions. This study examined the utility of linguistic measures derived from a short narrative language sample for 1) identifying language characteristics and cut-off scores to differentiate between healthy aging, Primary Progressive Aphasia (PPA), Mild Cognitive Impairment (MCI), and Alzheimer's dementia (AD); and 2) differentiating among PPA variants in which language is the primary impairment.

Method

Participants were 25 neurologically healthy English speakers, 20 individuals with MCI, 20 with AD, and 26 with PPA (non-fluent/agrammatic N = 10, logopenic N = 9, semantic N = 7). Narrative language samples of the

SUBMITTER: Faroqi-Shah Y 

PROVIDER: S-EPMC7304645 | biostudies-literature | 2020 May - Jun

REPOSITORIES: biostudies-literature