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A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy.


ABSTRACT: To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.

SUBMITTER: Chesnais CB 

PROVIDER: S-EPMC7304933 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy.

Chesnais Cédric B CB   Bizet Charlotte C   Campillo Jérémy T JT   Njamnshi Wepnyu Y WY   Bopda Jean J   Nwane Philippe P   Pion Sébastien D SD   Njamnshi Alfred K AK   Boussinesq Michel M  

Open forum infectious diseases 20200602 6


To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose <i>Onchocerca volvulus</i> microfilarial density (<i>Ov</i>-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.  ...[more]

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