Ontology highlight
ABSTRACT:
SUBMITTER: Son SM
PROVIDER: S-EPMC7305105 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Son Sung Min SM Park So Jung SJ Stamatakou Eleanna E Vicinanza Mariella M Menzies Fiona M FM Rubinsztein David C DC
Nature communications 20200619 1
Macroautophagy ("autophagy") is the main lysosomal catabolic process that becomes activated under nutrient-depleted conditions, like amino acid (AA) starvation. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy. While leucine (Leu) is a critical mTORC1 regulator under AA-starved conditions, how Leu regulates autophagy is poorly understood. Here, we describe that in most cell types, including neurons, Leu negatively regulates autophagosome ...[more]