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Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

ABSTRACT: Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS) EEG delta (?-)power are widely used as proxy for a sleep homeostatic process. Here, we noted frequency increases in ?-waves in sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We identified two classes of ?-waves; one responding to sleep deprivation with high initial power and fast, discontinuous decay during recovery sleep (?2) and another unrelated to time-spent-awake with slow, linear decay (?1). Reanalysis of previously published datasets demonstrates that ?-band heterogeneity after sleep deprivation is also present in human subjects. Similar to sleep deprivation, silencing of centromedial thalamus neurons boosted subsequent ?2-waves, specifically. ?2-dynamics paralleled that of temperature, muscle tone, heart rate, and neuronal ON-/OFF-state lengths, all reverting to characteristic NREMS levels within the first recovery hour. Thus, prolonged waking seems to necessitate a physiological recalibration before typical NREMS can be reinstated.

SUBMITTER: Hubbard J

PROVIDER: S-EPMC7305232 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

Hubbard Jeffrey J Gent Thomas C TC Hoekstra Marieke M B MMB Emmenegger Yann Y Mongrain Valerie V Landolt Hans-Peter HP Adamantidis Antoine R AR Franken Paul P

Nature communications 20200619 1

Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) sleep (NREMS) EEG delta (δ-)power are widely used as proxy for a sleep homeostatic process. Here, we noted frequency increases in δ-waves in sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate to prior sleep-wake history. We identified two classes of δ-waves; one responding to sleep deprivation with high initial power and fast, discontinuous decay during recovery sleep (δ2) and another unrelated to ...[more]

PMID: 32561733

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Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

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Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.

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