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Rate and Determinants of Excessive Fat-Free Mass Loss After Bariatric Surgery.


ABSTRACT: PURPOSE:Fat-free mass (FFM) loss is a concerning aspect of bariatric surgery, but little is known about its time-course and factors related with excessive FFM loss. This study examined (i) the progress of FFM loss up to 3 years post-bariatric surgery and (ii) the prevalence and determinants of excessive FFM loss. MATERIALS AND METHODS:A total of 3596 patients (20% males, 43.5?±?11.1 years old, BMI?=?44.2?±?5.5 kg/m2) underwent sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) surgery. Bioelectrical impedance analysis was performed preoperatively and 3, 6, 9, 12, 18, 24 and 36 months post-surgery. Changes in body composition were assessed by mixed model analysis. Prevalence of excessive FFM loss (based on three different cutoff values: ??25%, ??30% and ??35% FFM loss/weight loss (=?%FFML/WL)) was estimated and its determinants were assessed by linear regression analysis. RESULTS:Highest rates of FFM loss were found at 3 and 6 months post-surgery, reflecting 57% and 73% of peak FFM loss, respectively. Prevalence of excessive FFM loss ranged from 14 to 46% at 36 months post-surgery, with an older age (??=?0.14, 95%CI?=?0.10-0.18, P?

SUBMITTER: Nuijten MAH 

PROVIDER: S-EPMC7305251 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Rate and Determinants of Excessive Fat-Free Mass Loss After Bariatric Surgery.

Nuijten Malou A H MAH   Monpellier Valerie M VM   Eijsvogels Thijs M H TMH   Janssen Ignace M C IMC   Hazebroek Eric J EJ   Hopman Maria T E MTE  

Obesity surgery 20200801 8


<h4>Purpose</h4>Fat-free mass (FFM) loss is a concerning aspect of bariatric surgery, but little is known about its time-course and factors related with excessive FFM loss. This study examined (i) the progress of FFM loss up to 3 years post-bariatric surgery and (ii) the prevalence and determinants of excessive FFM loss.<h4>Materials and methods</h4>A total of 3596 patients (20% males, 43.5 ± 11.1 years old, BMI = 44.2 ± 5.5 kg/m<sup>2</sup>) underwent sleeve gastrectomy (SG) or Roux-en-Y gastri  ...[more]

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