Unknown

Dataset Information

0

Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction.

ABSTRACT: Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated. In this study, we found that ablating the ventral medial midbrain/pons (VMP) GABAergic neurons induced mania-like behaviors in mice, including hyperactivity, anti-depressive behaviors, reduced anxiety, increased risk-taking behaviors, distractibility, and an extremely shortened sleep time. Strikingly, these mice also showed no rebound sleep after sleep deprivation, suggesting abnormal sleep homeostatic regulation. Dopamine D2 receptor deficiency largely abolished the sleep reduction induced by ablating the VMP GABAergic neurons without affecting the hyperactivity and anti-depressive behaviors. Our data demonstrate that VMP GABAergic neurons are involved in the expression of mania-like behaviors, which can be segregated to the short-sleep and other phenotypes on the basis of the dopamine D2 receptors.

SUBMITTER: Honda T 

PROVIDER: S-EPMC7305386 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D<sub>2</sub>R-mediated Sleep Reduction.

Honda Takato T   Takata Yohko Y   Cherasse Yoan Y   Mizuno Seiya S   Sugiyama Fumihiro F   Takahashi Satoru S   Funato Hiromasa H   Yanagisawa Masashi M   Lazarus Michael M   Oishi Yo Y  

iScience 20200604 6

Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated. In this study, we found that ablating the ventral medial midbrain/pons (VMP) GABAergic neurons induced mania-like behaviors in mice, including hyperactivity, anti-depressive behaviors, reduced anxiety, increased risk-taking behaviors, distractibility, and an extremel  ...[more]

Similar Datasets

Unknown Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior.
| S-EPMC8589652 | biostudies-literature
Unknown Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit.
| S-EPMC6664144 | biostudies-literature
Unknown Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.
| S-EPMC8651008 | biostudies-literature
Unknown Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake.
| S-EPMC9097974 | biostudies-literature
Transcriptomics Human-specific transcriptome of ventral and dorsal midbrain dopamine neurons
2021-02-03 | GSE166024 | GEO
Unknown Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons.
| S-EPMC4896488 | biostudies-literature
Unknown Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling.
| S-EPMC6300565 | biostudies-literature
Unknown Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons.
| S-EPMC10957172 | biostudies-literature
Unknown Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors.
| S-EPMC6202358 | biostudies-literature
Unknown Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.
| S-EPMC6122951 | biostudies-literature