Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7305813 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Li Wu W Feng Yong Y Chen Anhai A Li Taoxi T Huang Sida S Liu Jing J Liu Xianlin X Liu Yalan Y Gao Jiangang J Yan Denise D Sun Jie J Mei Lingyun L Liu Xuezhong X Ling Jie J
Human molecular genetics 20191201 24
ELMOD3, an ARL2 GTPase-activating protein, is implicated in causing hearing impairment in humans. However, the specific role of ELMOD3 in auditory function is still far from being elucidated. In the present study, we used the CRISPR/Cas9 technology to establish an Elmod3 knockout mice line in the C57BL/6 background (hereinafter referred to as Elmod3-/- mice) and investigated the role of Elmod3 in the cochlea and auditory function. Elmod3-/- mice started to exhibit hearing loss from 2 months of a ...[more]