Ontology highlight
ABSTRACT:
SUBMITTER: Liao J
PROVIDER: S-EPMC7305835 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liao Jipei J Yang Zejia Z Carter-Cooper Brandon B Chang Elizabeth T ET Choi Eun Yong EY Kallakury Bhaskar B Liu Xuefeng X Lapidus Rena G RG Cullen Kevin J KJ Dan Hancai H
Clinical & experimental metastasis 20200204 2
We explored the role of the transcription factor, NF-κB, and its upstream kinase IKKβ in regulation of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma (HNSCC). We showed that cisplatin-resistant HNSCC cells have a stronger ability to migrate and invade, as well as display higher IKKβ/NF-κB activity compared to their parental partners. Importantly, we found that knockdown of IKKβ, but not NF-κB, dramatically impaired cell migration and invasion in ...[more]