Ontology highlight
ABSTRACT:
SUBMITTER: Westbrook JD
PROVIDER: S-EPMC7305983 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Westbrook John D JD Soskind Rose R Hudson Brian P BP Burley Stephen K SK
Drug discovery today 20200214 5
Open access to 3D structure information from the Protein Data Bank (PDB) facilitated discovery and development of >90% of the 79 new antineoplastic agents (54 small molecules, 25 biologics) with known molecular targets approved by the FDA 2010-2018. Analyses of PDB holdings, the scientific literature and related documents for each drug-target combination revealed that the impact of public-domain 3D structure data was broad and substantial, ranging from understanding target biology (∼95% of all t ...[more]