Ontology highlight
ABSTRACT:
SUBMITTER: Bylicki O
PROVIDER: S-EPMC7306460 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Bylicki Olivier O Paleiron Nicolas N Assié Jean-Baptiste JB Chouaïd Christos C
OncoTargets and therapy 20200617
The c-MET proto-oncogene (MET) plays an important role in lung oncogenesis, affecting cancer-cell survival, growth and invasiveness. The MET receptor in non-small-cell lung cancer (NSCLC) is a potential therapeutic target. The development of high-output next-generation sequencing techniques has enabled better identification of anomalies in the MET pathway, like the MET exon-14 (METex14) mutation. Moreover, analyses of epidermal growth factor-receptor (EGFR) and mechanisms of resistance to tyrosi ...[more]