Ontology highlight
ABSTRACT:
SUBMITTER: Balazki P
PROVIDER: S-EPMC7306617 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Balazki Pavel P Schaller Stephan S Eissing Thomas T Lehr Thorsten T
CPT: pharmacometrics & systems pharmacology 20200616 6
Incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play a major role in regulation of postprandial glucose and the development of type 2 diabetes mellitus. The incretins are rapidly metabolized, primarily by the enzyme dipeptidyl-peptidase 4 (DPP4), and the neutral endopeptidase (NEP), although the exact metabolization pathways are unknown. We developed a physiologically-based (PB) quantitative systems pharmacology model of GLP-1 and GIP and ...[more]