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Validation of Parkinson's Disease-Related Questionnaires in South Africa.

ABSTRACT: Background:There are very few epidemiological studies investigating Parkinson's disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use. Objective:The objective of the study was to validate two commonly used PD questionnaires in an African population. Methods:The PD Screening Questionnaire (PDSQ) and Parkinson's Disease Questionnaire (PDQ-39) were modified and translated into Afrikaans, Setswana, and isiZulu and administered to a sample of healthy local residents. We assessed the internal consistencies and cluster characteristics of the questionnaires, using a Cronbach's alpha test and exploratory factor analysis. The questionnaires were then administered to a population-based sample of 416 research participants. We evaluated the correlations between the questionnaires and both a timed motor task and the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3), using locally weighted scatterplot smoothing (LOWESS) regression analysis and Spearman's rank correlation. Results:Both questionnaires had high overall internal consistency (Cronbach's alpha?=?0.86 and 0.95, respectively). The modified PDQ-39 had evidence of five subscales, with Factor 1 explaining 57% and Factor 2 explaining 14%, of the variance in responses. The PDSQ and PDQ-39 scores were correlated with the UPDRS3 score (??=?0.35, P < 0.001; and ??=?0.28, P < 0.001, respectively). Conclusion:The translated PDSQ and PDQ-39 questionnaires demonstrated high internal consistency and correlations with clinical severity of parkinsonism and a timed motor task, suggesting that they are valid tools for field-based epidemiological studies.

SUBMITTER: Nelson G

PROVIDER: S-EPMC7306845 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Validation of Parkinson's Disease-Related Questionnaires in South Africa.

Nelson Gill G Ndlovu Ntombizodwa N Christofides Nicola N Hlungwani Tintswalo M TM Faust Irene I Racette Brad A BA

Parkinson's disease 20200613

<h4>Background</h4>There are very few epidemiological studies investigating Parkinson's disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use.<h4>Objective</h4>The objective of the study was to validate two commonly used PD questionnaires in an African population.<h4>Methods</h4>The PD Screening Questionnaire (PDSQ) and Parkinson's Disease Questionnaire (PDQ-39) were modified and translated into Afrikaans, S ...[more]

PMID: 32617145

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Validation of Parkinson's Disease-Related Questionnaires in South Africa.

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Validation of Parkinson's Disease-Related Questionnaires in South Africa.

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