Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: Barthelson K
PROVIDER: S-EPMC7306921 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Sorting Out the Role of the <i>Sortilin-Related Receptor 1</i> in Alzheimer's Disease.
Barthelson Karissa K Newman Morgan M Lardelli Michael M
Journal of Alzheimer's disease reports 20200502 1
<i>Sortilin-related receptor 1 (SORL1)</i> encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. <i>SORL1</i> is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we rev ...[more]
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