Ontology highlight
ABSTRACT:
SUBMITTER: Logunova NN
PROVIDER: S-EPMC7306996 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Logunova Nadezhda N NN Kriukova Valeriia V VV Shelyakin Pavel V PV Egorov Evgeny S ES Pereverzeva Alina A Bozhanova Nina G NG Shugay Mikhail M Shcherbinin Dmitrii S DS Pogorelyy Mikhail V MV Merzlyak Ekaterina M EM Zubov Vasiliy N VN Meiler Jens J Chudakov Dmitriy M DM Apt Alexander S AS Britanova Olga V OV
Proceedings of the National Academy of Sciences of the United States of America 20200601 24
T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) context. Complementarity-determining region 3 (CDR3) is the most variable part of the TCRα and -β chains, which govern interactions with peptide-MHC complexes. However, it remains unclear how the CDR3 landscape is shaped by individual MHC context during thymic selection of naïve T cells. We established two mouse stra ...[more]