Ontology highlight
ABSTRACT:
SUBMITTER: Pandya AD
PROVIDER: S-EPMC7307886 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pandya Abhilash D AD Øverbye Anders A Sahariah Priyanka P Gaware Vivek S VS Høgset Håkon H Masson Màr M Høgset Anders A Mælandsmo Gunhild M GM Skotland Tore T Sandvig Kirsten K Iversen Tore-Geir TG
Biomacromolecules 20200305 4
In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC-CS NPs have high loading capacity and strong drug retention due to π-π stacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chai ...[more]