Ontology highlight
ABSTRACT:
SUBMITTER: Mancini A
PROVIDER: S-EPMC7308048 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Mancini Alessandra A Howard Sasha R SR Marelli Federica F Cabrera Claudia P CP Barnes Michael R MR Sternberg Michael Je MJ Leprovots Morgane M Hadjidemetriou Irene I Monti Elena E David Alessia A Wehkalampi Karoliina K Oleari Roberto R Lettieri Antonella A Vezzoli Valeria V Vassart Gilbert G Cariboni Anna A Bonomi Marco M Garcia Marie Isabelle MI Guasti Leonardo L Dunkel Leo L
JCI insight 20200604 11
The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed puberty (DP) affects up to 2% of the population, is highly heritable, and is associated with adverse health outcomes, the genes underlying DP remain largely unknown. We aimed to discover regulators by whole-exome sequencing of 160 individuals of ...[more]