Ontology highlight
ABSTRACT:
SUBMITTER: de Cubas AA
PROVIDER: S-EPMC7308050 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
de Cubas Aguirre A AA Dunker William W Zaninovich Andrew A Hongo Rachel A RA Bhatia Anuj A Panda Anshuman A Beckermann Kathryn E KE Bhanot Gyan G Ganesan Shridar S Karijolich John J Rathmell W Kimryn WK
JCI insight 20200604 11
Recently, we reported that expression of endogenous retroviruses (ERVs) is associated with response to immune checkpoint blockade (ICB) in renal cell carcinoma (RCC). We show that decitabine, a DNA hypomethylating agent, activates transposable element (TE) expression (LINE1 and ERVs ERV3-2 and ERV4700) and antiviral signaling to potentially enhance response to ICB in kidney cancer cell lines and primary cells. KO of RIGI and MDA5 dsRNA sensors attenuated activation of antiviral signaling associa ...[more]