Ontology highlight
ABSTRACT:
SUBMITTER: Podkalicka P
PROVIDER: S-EPMC7308053 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Podkalicka Paulina P Mucha Olga O Bronisz-Budzyńska Iwona I Kozakowska Magdalena M Pietraszek-Gremplewicz Katarzyna K Cetnarowska Anna A Głowniak-Kwitek Urszula U Bukowska-Strakova Karolina K Cieśla Maciej M Kulecka Maria M Ostrowski Jerzy J Mikuła Michał M Potulska-Chromik Anna A Kostera-Pruszczyk Anna A Józkowicz Alicja A Łoboda Agnieszka A Dulak Józef J
JCI insight 20200604 11
The severity of Duchenne muscular dystrophy (DMD), an incurable disease caused by the lack of dystrophin, might be modulated by different factors, including miRNAs. Among them, miR-378 is considered of high importance for muscle biology, but intriguingly, its role in DMD and its murine model (mdx mice) has not been thoroughly addressed so far. Here, we demonstrate that dystrophic mice additionally globally lacking miR-378 (double-KO [dKO] animals) exhibited better physical performance and improv ...[more]