Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
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ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC7308060 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
Yang Li L Shivakumar Pranavkumar P Kinder Jeremy J Way Sing Sing SS Donnelly Bryan B Mourya Reena R Luo Zhenhua Z Bezerra Jorge A JA
JCI insight 20200604 11
Extramedullary hematopoietic cells are present in the liver of normal neonates in the first few days of life and persist in infants with biliary atresia. Based on a previous report that liver genes are enriched by erythroid pathways, we examined the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age. Using immunostaining, anti-CD71 antibodies identified CD71+ ...[more]
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