Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC7308061 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhu Luchang L Olsen Randall J RJ Beres Stephen B SB Saavedra Matthew Ojeda MO Kubiak Samantha L SL Cantu Concepcion C CC Jenkins Leslie L Waller Andrew S AS Sun Zhizeng Z Palzkill Timothy T Porter Adeline R AR DeLeo Frank R FR Musser James M JM
JCI insight 20200604 11
Streptococcus pyogenes (group A streptococcus; GAS) causes 600 million cases of pharyngitis annually worldwide. There is no licensed human GAS vaccine despite a century of research. Although the human oropharynx is the primary site of GAS infection, the pathogenic genes and molecular processes used to colonize, cause disease, and persist in the upper respiratory tract are poorly understood. Using dense transposon mutant libraries made with serotype M1 and M28 GAS strains and transposon-directed ...[more]