Ontology highlight
ABSTRACT:
SUBMITTER: Madenspacher JH
PROVIDER: S-EPMC7308063 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Madenspacher Jennifer H JH Morrell Eric D ED Gowdy Kymberly M KM McDonald Jeffrey G JG Thompson Bonne M BM Muse Ginger G Martinez Jennifer J Thomas Seddon S Mikacenic Carmen C Nick Jerry A JA Abraham Edward E Garantziotis Stavros S Stapleton Renee D RD Meacham Julie M JM Thomassen Mary Jane MJ Janssen William J WJ Cook Donald N DN Wurfel Mark M MM Fessler Michael B MB
JCI insight 20200604 11
Alveolar macrophages (AM) play a central role in initiation and resolution of lung inflammation, but the integration of these opposing core functions is poorly understood. AM expression of cholesterol 25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds the expression of macrophages in other tissues, but no role for CH25H has been defined in lung biology. As 25HC is an agonist for the antiinflammatory nuclear receptor, liver X receptor (LXR), we s ...[more]