Ontology highlight
ABSTRACT:
SUBMITTER: Balestra AC
PROVIDER: S-EPMC7308089 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
eLife 20200622
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. We show that <i>Plasmodium berghei</i> CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. It phosphorylates cano ...[more]