Ontology highlight
ABSTRACT:
SUBMITTER: Seitz V
PROVIDER: S-EPMC7308335 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Seitz V V Kleo K K Dröge A A Schaper S S Elezkurtaj S S Bedjaoui N N Dimitrova L L Sommerfeld A A Berg E E von der Wall E E Müller U U Joosten M M Lenze D D Heimesaat M M MM Baldus C C Zinser C C Cieslak A A Macintyre E E Stocking C C Hennig S S Hummel M M
Scientific reports 20200622 1
T-cell receptor gene beta (TCRβ) gene rearrangement represents a complex, tightly regulated molecular mechanism involving excision, deletion and recombination of DNA during T-cell development. RUNX1, a well-known transcription factor for T-cell differentiation, has recently been described to act in addition as a recombinase cofactor for TCRδ gene rearrangements. In this work we employed a RUNX1 knock-out mouse model and demonstrate by deep TCRβ sequencing, immunostaining and chromatin immunoprec ...[more]