Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis.

ABSTRACT: Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57?±?4 vs 64?±?5%, P?

SUBMITTER: Andreasen L 

PROVIDER: S-EPMC7308347 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature