Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez-Gonzalez C
PROVIDER: S-EPMC7308386 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Dominguez-Gonzalez Cristina C Badosa Carmen C Madruga-Garrido Marcos M Martí Itxaso I Paradas Carmen C Ortez Carlos C Diaz-Manera Jordi J Berardo Andres A Alonso-Pérez Jorge J Trifunov Selena S Cuadras Daniel D Kalko Susana G SG Blázquez-Bermejo Cora C Cámara Yolanda Y Martí Ramon R Mavillard Fabiola F Martin Miguel A MA Montoya Julio J Ruiz-Pesini Eduardo E Villarroya Joan J Montero Raquel R Villarroya Francesc F Artuch Rafael R Hirano Michio M Nascimento Andrés A Jimenez-Mallebrera Cecilia C
Scientific reports 20200622 1
GDF-15 is a biomarker for mitochondrial diseases. We investigated the application of GDF-15 as biomarker of disease severity and response to deoxynucleoside treatment in patients with thymidine kinase 2 (TK2) deficiency and compared it to FGF-21. GDF-15 and FGF-21 were measured in serum from 24 patients with TK2 deficiency treated 1-49 months with oral deoxynucleosides. Patients were grouped according to age at treatment and biomarkers were analyzed at baseline and various time points after trea ...[more]