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Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow.

ABSTRACT: The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

SUBMITTER: Nyuchev AV

PROVIDER: S-EPMC7308607 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow.

Nyuchev Alexander V AV Wan Ting T Cendón Borja B Sambiagio Carlo C Struijs Job J C JJC Ho Michelle M Gulías Moisés M Wang Ying Y Noël Timothy T

Beilstein journal of organic chemistry 20200615

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions. ...[more]

PMID: 32595778

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