Unknown

Dataset Information

0

Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts.

ABSTRACT: A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.

SUBMITTER: Neerbye Berntsen L 

PROVIDER: S-EPMC7309330 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Cu-catalyzed <i>N</i>-3-Arylation of Hydantoins Using Diaryliodonium Salts.

Neerbye Berntsen Linn L   Nova Ainara A   Wragg David S DS   Sandtorv Alexander H AH  

Organic letters 20200323 7

A general Cu-catalyzed, regioselective method for the <i>N</i>-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutical  ...[more]

Similar Datasets

Unknown Cu-catalyzed fluorination of diaryliodonium salts with KF.
| S-EPMC4096328 | biostudies-literature
Unknown Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines.
| S-EPMC5065240 | biostudies-literature
Unknown Enantioselective and Regiodivergent Copper-Catalyzed Electrophilic Arylation of Allylic Amides with Diaryliodonium Salts.
| S-EPMC4569064 | biostudies-literature
Unknown Copper-Catalyzed Synthesis of Axially Chiral Biaryls with Diaryliodonium Salts as Arylation Reagents.
| S-EPMC8199266 | biostudies-literature
Unknown Arylation with unsymmetrical diaryliodonium salts: a chemoselectivity study.
| S-EPMC3884774 | biostudies-literature
Unknown 1-Arylation of 1,4-Benzodiazepine-2-ones with Diaryliodonium Salts.
| S-EPMC6193364 | biostudies-other
Unknown Combining Transition Metal Catalysis with Radical Chemistry: Dramatic Acceleration of Palladium-Catalyzed C-H Arylation with Diaryliodonium Salts.
| S-EPMC3740597 | biostudies-literature
Unknown Palladium-catalyzed direct ?-arylation of ketones with diaryliodonium salts: a stoichiometric heavy metal-free and user-friendly approach.
| S-EPMC5949602 | biostudies-literature
Unknown Mechanistic Investigations of Cu-Catalyzed Fluorination of Diaryliodonium Salts: Elaborating the CuI/CuIII Manifold in Copper Catalysis.
| S-EPMC4195515 | biostudies-literature
Unknown Palladium-catalyzed synthesis of N-arylated carbazoles using anilines and cyclic diaryliodonium salts.
| S-EPMC3701385 | biostudies-literature