Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke.

ABSTRACT:

Introduction

Bleeding is the main safety concern of treatment with antiplatelet drugs. We aimed to refine prediction of major bleeding on antiplatelet treatment after a transient ischaemic attack (TIA) or stroke by assessing the added value of new predictors to the existing S₂TOP-BLEED score.

Patients and methods

We used Cox regression analysis to study the association between candidate predictors and major bleeding among 2072 patients with a transient ischaemic attack or ischaemic stroke included in a population-based study (Oxford Vascular Study - OXVASC). An updated model was proposed and validated in 1094 patients with a myocardial infarction included in OXVASC. Models were compared with c-statistics, calibration plots, and net reclassification improvement.

SUBMITTER: Hilkens NA 

PROVIDER: S-EPMC7309362 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature